WOUND HEALING and TOXICITY EVALUATION of ALOE VERA CREAM ON OUTPATIENTS WITH SECOND DEGREE BURNS

There are numerous cases of the second-degree burns in the homes or the countries struggling for the better treatment policies. The tall leaves of Aloe Vera consist of a gel which contains 99% of water and also monosaccharides like mannose-6-phosphate and polysaccharides like accemanan.

As Aloe Vera has significant healing effects, a study was conducted to assess the dermal toxicity of the new formulated Aloe gel on human skin & measure the percentage of healing of the wounds with the second-degree burns. A cream was formulated with Aloe Vera and Patients of ages between 20 – 50 years were selected for the study, 20 of the patients were male and the rest 10 were females. The test was conducted by applying 1% of the silver sulfadiazine cream and the Aloe cream on each hand. The results evaluated after the 18 days of treatment stated that about 90.6% of the wounds were already healed at the day 10 of the course with the Aloe cream while the average rate of healing from the silver sulfadiazine was only 29.8%. Patients were asked about the response during the course, they stated that with the Aloe Vera on the burn wounds, there were no rashes, redness, irritation, itching or any other toxic effect.

 

MATERIALS AND METHODS

1) Materials:

 

In order to conduct the study, the leaves of Aloe plant were collected from the botanic garden of the Faculty of Pharmacy in the university, in spring and were identified by the Department of Horticulture.

The gel was extracted out of the fresh leaves by squeezing the paranshim cells and determined with the trifling heat of about 40 – 50OC under a laminar air flow. The rotatory evaporator & soxellete procedure were used to obtain the 93 % yield of the extract.

 

2) Formulation preparation:

The formulation prepared with the emulsified base was amalgamated at 70-75oC on a water bath.

The oily segment has stearyl alcohol, paraffin (liquid), wool fat and eucerine. Sodium lauryl sulfate, methyl paraben, propyl paraben and propylene glycol were used for the preparation of the water phase.

 

3) Clinical Study:

 

The patients (20 males and 10 females) with second degree burn wounds were selected for the study. The Aloe Vera formulation and the silver sulfadiazine 1% cream were applied on each hand for the test and they were monitored after every 24 hour to calculate the rate of wound healing. No amount of healing was observed on the very first day of the study and later the wound healing were compared with the wounds of the day one of the study.

 

4) Results:

 

The 3 month period of the chemical and physical test results evaluated that the most firm product could be formulated at the pH 5.3.

Also, the Aloe Vera started affecting and healing the wounds from the day one and it was observed on the day three that aloe Vera was healing 14 times better and quicker than the 1% cream of silver sulfadiazine.

Out of 30, the 20 patients were completely healed after 10 days and the 9 patients were healed after 18 days and only one patient was still found septic. Hence, the Aloe Vera was found to be one half shorter than the treatment of Silver Sulfadiazine.

 

Posted by aloeveramart17

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